The archaeological and historic objects that we can admire in the permanent exhibition rooms belong to the museum's own collecton, and they are enriched with loans from other institutions such as the Viceregal National Museum as well as from private collections among which stands out that of the antiquarian Rodrigo Rivero Lake.

These objects conform a notable heritage, since they speak about far away worlds that were brought together for more than two centuries through a commercial trade route, as well as speak about the region of the State of Guerrero with its interesting archaelogical cultures such as the culture of Mezcala, integrated with Mayan and Olmec influences, mixed with local groups, that achieved to create ceremonial centers and a complex of figurines and masks with strong geometric traces known as Mezcala style.

The Mezcala Style has been defined by the portable sculptures or figurines and flattened masks made with thick rims, lines and hollows dsitributed with a great plastic sense and symmetrically spread within a rectangular or trapezoidal face, around a rim in the form of a T that constitutes the eyebrows and nose. Numerous representations of animals, utensils, architectural models and representations of ball game constructions have also been found.

The Museum counts with services such as a ticket counter, store, auditorium, an educational services department that offers guided tours of the exhibition rooms as well as of the fortress itself, a temporary exhibitions room, ample parking space, gardens that show the visitor the species peculiar to tropical forrests and, above all, a magnificent view of the port and the incomparable Bay of Santa Lucía.

Acapulco represents the entrance door of all the merchandise and influences of cultures native of various continents, it is a crossroad of races and peoples, home to the famous Manila Galleon and of its fairs. The Museum safekeeps the most distinguished part of this history.